Drug-Induced Epigenetic Changes Produce Drug Tolerance
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چکیده
منابع مشابه
Drug-Induced Epigenetic Changes Produce Drug Tolerance
Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations. The slo gene encodes the pore-forming subunit of BK-type Ca(2+)-activated K(+) channels, which regulate many aspects of neural activity. Gi...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2007
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050265